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Isocyanic acid → 3,6-Dibutyl-2,5-dimethylpyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isocyanic acid | HCID 6347 | — |
| 反応物 | 2-Heptanone | HCID 8051 | — |
| 反応物 | Nitrosyl chloride | HCID 17601 | — |
| 反応物 | 3-Hydroxyiminoheptan-2-one | HCID 57349923 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3,6-Dibutyl-2,5-dimethylpyrazine | HCID 601225 | — |
反応手順
2,5-Dimethyl-3,6-dibutyl-pyrazine was prepared by first forming 3-oximino-2-heptanone by reacting 2-heptanone with nitrosyl chloride according to the method of BOUVEAULT, Bull. [3] 31, 1163 (1904). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-dimethyl-3,6-dibutyl-pyrazine which had a b.p. of 18° C./0.002 mm. Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04303689 |
| 出典データセット | uspto-grants-1981_12 |
| ORD ID | ord-4939d8f6006442dda57009b6a19dbed1 |
| 出典メモ | uspto-grants-1981_12 |