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Hydrochloric Acid → 2-[(2-Oxotetrahydro-3-furanyl)sulfanyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Mercaptobenzoic Acid | HCID 5443 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2(3H)-Furanone, 3-bromodihydro- | HCID 95463 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-[(2-Oxotetrahydro-3-furanyl)sulfanyl]benzoic acid | HCID 13622276 | 84.1% |
反応手順
In 250 ml of water are dissolved 25 g of thiosalicylic acid and 60 g of sodium carbonate. Then, under ice-cooling, 38 g of α-bromo-γ-butyrolactone is added dropwise. The mixture is stirred at room temperature for 3 hours. The reaction mixture is made acidic with dilute hydrochloric acid and the resultant precipitate is recovered by filtration, rinsed with water and recrystallized from ethanol. By the above procedure there is obtained 32.5 g of α-[(2-carboxyphenyl)thio]-γ-butyrolactone as colorless prisms melting at 180°-182° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04304784 |
| 出典データセット | uspto-grants-1981_12 |
| ORD ID | ord-7de1dec7d360495e8718f7b62c4fa06e |
| 出典メモ | uspto-grants-1981_12 |