Triethyl phosphite → Diethyl (3-ethylisoxazol-5-yl)-methanephosphonate
反応式
Cl[CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][CH3:9])[CH:4]=1.[P:10]([O:17]CC)([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]>>[CH2:8]([C:5]1[CH:4]=[C:3]([CH2:2][P:10]([O:14][CH2:15][CH3:16])(=[O:17])[O:11][CH2:12][CH3:13])[O:7][N:6]=1)[CH3:9]参加物
3
実験手順
15 g of 5-chloromethyl-3-ethyl-isoxazole and 18 g of triethyl phosphite are slowly heated to 150° C. and kept at this temperature for 21/2 hours. After cooling, the residue is distilled under reduced pressure. 18.2 g of diethyl (3-ethylisoxazol-5-yl)-methanephosphonate, of boiling point 120°-121° C./0.2 mm Hg are obtained. Yield: 71.2%.
後処理
- custom2 hours
- temperatureAfter cooling
- distillationthe residue is distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-dd201e48fb17420e90403ba6831e7a52
- 出典データセット
- uspto-grants-1981_12
- 特許番号
- US04305951
反応ノート
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