Quinoline → cis-2,5-Dimethyl-3-hexene-2,5-diol

HRID 1660371ノート

反応式

HRID 1660371 の反応式
C(=O)([O-])[O-].[Ca+2].N1C2C(=CC=CC=2)C=CC=1.[CH3:16][C:17]([OH:25])([C:19]#[C:20][C:21]([CH3:24])([OH:23])[CH3:22])[CH3:18].[H][H]>CO>[CH3:16][C:17]([OH:25])(/[CH:19]=[CH:20]\[C:21]([CH3:24])([OH:23])[CH3:22])[CH3:18]

参加物

6

反応物 4

HCID 7047QuinolineHCID 88832,5-Dimethyl-3-hexyne-2,5-diolHCID 10112Calcium CarbonateHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 11126394cis-2,5-Dimethyl-3-hexene-2,5-diol収率 99.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1.6 g of 5% palladized calcium carbonate and 0.6 g of quinoline were added to a solution of 24 g of 2,5-dimethyl-hex-3-yne-2,5-diol [Ray et al, Am. Soc., Vol. 74 (1952), p. 1247]in 200 ml of methanol and the mixture was stirred with hydrogen until hydrogen absorption ceased. The catalyst was removed by filtration and the filtrate was evaporated to dryness under reduced pressure to obtain 24.2 g of cis 2,5-dimethyl-hex-3-ene-2,5-diol melting at 64° C. which was used as is for the next step.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-30984089630f4520a4e0deabcbb2ad91
出典データセット
uspto-grants-1981_12
特許番号
US04307244

反応ノート

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