1,1'-(Diazomethylene)bis(benzene) → 2-Benzhydryloxycarbonyl-7-tert.-butoxycarbonylamino-3-methylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane

HRID 1660375ノート

反応式

HRID 1660375 の反応式
[C:1]([CH:4]1[C:11](=[CH2:12])[CH2:10][S:9][CH:8]2[N:5]1[C:6](=[O:21])[CH:7]2[NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])([OH:3])=[O:2].[C:22]1([C:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[N+]=[N-])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(OCC)(=O)C>[CH:28]([O:2][C:1]([CH:4]1[C:11](=[CH2:12])[CH2:10][S:9][CH:8]2[N:5]1[C:6](=[O:21])[CH:7]2[NH:13][C:14]([O:16][C:17]([CH3:18])([CH3:20])[CH3:19])=[O:15])=[O:3])([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

参加物

4

反応物 2

HCID 612301,1'-(Diazomethylene)bis(benzene)HCID 128967732-Carboxy-7-tert.-butoxycarbonylamino-3-methylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane

生成物 1

HCID 128967752-Benzhydryloxycarbonyl-7-tert.-butoxycarbonylamino-3-methylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane収率 66.2%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2-Carboxy-7-tert.-butoxycarbonylamino-3-methylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane (21.3 g) is esterified with diphenyldiazomethane (11.2 g) in accordance with the procedure of Example 1. 2-Benzhydryloxycarbonyl-7-tert.-butoxycarbonylamino-3-methylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane (18.35 g) is obtained in the form of white crystals (m.p.=135°-7° C. after recrystallisation from ethyl acetate).

出典と根拠

ORDレコード
ord-a0d44ef5d61644aa84636dc9c5cc8414
出典データセット
uspto-grants-1981_12
特許番号
US04307233

反応ノート

読み込み中…