4-Iodo-3-(trifluoromethyl)aniline → 2-(4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-(4-iodo-3-trifluoromethyl-phenyl)-acetamide
反応式
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[CH:2]=1.[I:20][C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][C:22]=1[C:28]([F:31])([F:30])[F:29]>C(Cl)Cl.CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([NH:27][C:24]3[CH:25]=[CH:26][C:21]([I:20])=[C:22]([C:28]([F:31])([F:29])[F:30])[CH:23]=3)=[O:19])=[CH:14][CH:15]=2)[CH:2]=1参加物
4
実験手順
The title compound is prepared as described in Example 1 but using (4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 7.1) and 4-iodo-3-trifluoromethyl-phenylamine. Title compound: ES-MS: 522.7 [M+H]+; single peak at tR=4.72 min (System 1); Rf=0.25 (CH2Cl2/MeOH, 95:5).