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4-Hydrazinobenzoic acid → 4-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydrazinobenzoic acid | HCID 12089 | — |
| 反応物 | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid | HCID 974688 | — |
反応手順
To a suspension of 2.4 g (16 mmol) 4-hydrazino-benzoic acid in 12 mL toluene, 2.0 g of pivaloyl acetonitrile are added at rt. The suspension is heated to and kept under reflux for 12 h. After completion, the resulting reaction mixture is allowed to cool to rt. The precipitated product is isolated by filtration, washed with cold toluene and dried under high vacuum. [M+1]+=260.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030311B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-cc0f4202c7ad45a6903e387b1dfd118c |
| 出典メモ | uspto-grants-2011_10 |