4-Hydrazinobenzoic acid → 4-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid

HRID 1661003

反応式

HRID 1661003 の反応式
[NH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)[NH2:2].[C:12]([CH2:18][C:19]#[N:20])(=O)[C:13]([CH3:16])([CH3:15])[CH3:14]>C1(C)C=CC=CC=1>[NH2:20][C:19]1[N:1]([C:3]2[CH:4]=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=2)[N:2]=[C:12]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:18]=1

参加物

4

反応物 2

HCID 120894-Hydrazinobenzoic acidHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

生成物 1

HCID 9746884-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a suspension of 2.4 g (16 mmol) 4-hydrazino-benzoic acid in 12 mL toluene, 2.0 g of pivaloyl acetonitrile are added at rt. The suspension is heated to and kept under reflux for 12 h. After completion, the resulting reaction mixture is allowed to cool to rt. The precipitated product is isolated by filtration, washed with cold toluene and dried under high vacuum. [M+1]+=260.

後処理

  1. additionare added at rt
  2. temperatureThe suspension is heated to and
  3. temperatureunder reflux for 12 h
  4. customAfter completion, the resulting reaction mixture
  5. customThe precipitated product is isolated by filtration
  6. washwashed with cold toluene
  7. customdried under high vacuum

出典と根拠

ORDレコード
ord-cc0f4202c7ad45a6903e387b1dfd118c
出典データセット
uspto-grants-2011_10
特許番号
US08030311B2

関連ノート

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