Methyl isothiocyanate → HCID 178432727、化合物
反応式
[CH3:1][C:2]1[S:3][C:4]([C:8]([NH:10][NH2:11])=O)=[C:5]([CH3:7])[N:6]=1.[CH3:12][N:13]=[C:14]=[S:15]>C(O)C>[CH3:1][C:2]1[S:3][C:4]([C:8]2[N:13]([CH3:12])[C:14]([SH:15])=[N:11][N:10]=2)=[C:5]([CH3:7])[N:6]=1参加物
4
実験手順
To a 2,4-dimethylthiazole-5-carbohydrazide (Prep26, 23 g, 0.13 mol) in ethanol (100 ml), methyl isothiocyanate (49.1 g, 0.67 mol) was added. The mixture was refluxed overnight. Then the ethanol was partially removed under vacuum and the residue was filtered. The solid was dried under vacuum to afford 14 g of the title compound (y=46%).
後処理
- temperatureThe mixture was refluxed overnight
- customThen the ethanol was partially removed under vacuum
- filtrationthe residue was filtered
- customThe solid was dried under vacuum
出典と根拠
- ORDレコード
- ord-6a53f4a191fd4b9688199acb32574d83
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08030322B2
反応ノート
読み込み中…