Calcium N-(5-hydroxynicotinoyl)-L-glutamate → HCID 3087262、化合物
反応式
O[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:19]=1)[C:7]([NH:9][C@H:10]([C:16]([O-:18])=[O:17])[CH2:11][CH2:12][C:13]([O-:15])=[O:14])=[O:8].[Ca+2]>O>[C:7]([NH:9][C@H:10]([C:16]([OH:18])=[O:17])[CH2:11][CH2:12][C:13]([OH:15])=[O:14])(=[O:8])[C:6]1[CH:19]=[CH:2][CH:3]=[N:4][CH:5]=1参加物
3
実験手順
The study of acute daily toxicity of Compound I was carried out on white nondescript male mice with body weight 25-28 g, which lived in habitual conditions in vivarium and received feed and water ad libitum. Single dose of Compound I was administered intraperitoneally. The animals were under observation for 2 days after the dosing. The dose levels of Compound I used in the toxicity study were as follows: 800 mg/kg, 1000 mg/kg, 1200 mg/kg, 1500 mg/kg, 1600 mg/kg. Compound I was dissolved in distilled water and administered in 0, 1 ml per 10 g of the body weight of the animal when the doses 800 mg/kg and 1000 mg/kg, and in 0.2 ml per 10 g of the body weight when the doses 1200 mg/kg, 1500 mg/kg, 1600 mg/kg were used. Control animals received distilled water in the volume 0.2 ml per 10 g of the body weight.