Hydrochloric Acid → 5-Bromo-4-methoxy-2-methylaniline
反応式
[Br:1][C:2]1[C:3]([O:13][CH3:14])=[CH:4][C:5]([CH3:12])=[C:6]([NH:8]C(=O)C)[CH:7]=1.Cl.C([O-])(O)=O.[Na+]>CO>[Br:1][C:2]1[C:3]([O:13][CH3:14])=[CH:4][C:5]([CH3:12])=[C:6]([CH:7]=1)[NH2:8]参加物
5
実験手順
To a solution of N-(5-bromo-4-methoxy-2-methylphenyl)acetamide (108 g, 0.42 mol) in MeOH (400 mL) is added concentrated HCl (160 mL, 2 mol). After being heated at reflux overnight, the mixture is neutralized with aqueous NaHCO3, and extracted with EtOAc (1200 mL). The organic phase is dried and concentrated to afford the product (76 g, 84% yield). MS (m/z): 216.0 (M+H).
後処理
- temperatureAfter being heated
- temperatureat reflux overnight
- extractionextracted with EtOAc (1200 mL)
- customThe organic phase is dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-94e8432259714e7ea5444731554ddfd3
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08030302B2
反応ノート
読み込み中…