Diethyl Ether → 1-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole

HRID 1661988ノート

反応式

HRID 1661988 の反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][C:3]=1[OH:11].C([O:14][CH2:15][CH3:16])C.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:11][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:2]=1[Br:1])[N:8]([C:15](=[O:14])[CH3:16])[N:7]=[CH:6]2)(=[O:19])[CH3:18]

参加物

4

反応物 3

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 591599466-Bromo-1H-indazol-5-ol

生成物 1

HCID 667671231-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole収率 98%

反応条件

温度
110 °C

実験手順

A mixture of 6-bromo-5-hydroxy-1H-indazole (25 g, 117 mmol) in acetic acid anhydride (75 mL) is heated at 110° C. with stirring for 2 hours. After it is cooled, diethyl ether (100 mL) is added. The precipitate is collected by filtration, washed with diethyl ether (30 mL), and dried under vacuum to afford the product (34 g, 98% yield). MS (m/z): 297.0 (M+H).

後処理

  1. temperatureAfter it is cooled
  2. filtrationThe precipitate is collected by filtration
  3. washwashed with diethyl ether (30 mL)
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-10c222a328d84374bbe9263e5fb2ace3
出典データセット
uspto-grants-2011_10
特許番号
US08030302B2

反応ノート

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