Ammonia → (3R)-1-benzylpyrrolidin-3-amine

HRID 1662083

反応式

HRID 1662083 の反応式
[NH3:1].[CH2:2]([N:9]1[CH2:13][CH2:12][C@H:11](OS(C)(=O)=O)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>>[CH2:2]([N:9]1[CH2:13][CH2:12][C@@H:11]([NH2:1])[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 222Ammonia2 回HCID 10934081(S)-1-Benzyl-3-mesyloxypyrrolidine

生成物 1

HCID 1519354(3R)-1-benzylpyrrolidin-3-amine収率 88%

実験手順

An autoclave was cooled with an acetone/dry ice bath, and an ammonia gas was blown to pool 477 cc of liquid ammonia (corresponding to 25 equivalent of (S)-1-benzyl-3-(methanesulfonyloxy)pyrrolidine). Thereto was added 180 g of (S)-1-benzyl-3-(methanesulfonyloxy)pyrrolidine (672.1 mmol, optical purity: 100% e.e.), which was heated to 100° C. whereby an internal pressure of 55 barr was observed. After allowing the reaction for 5 hrs, the reaction mixture was cooled to room temperature, and ammonia was removed by distillation under reduced pressure. As the residue, 306.7 g of a brown oily material was obtained (reaction yield: 88%, optical purity: 91.2% e.e.).

後処理

  1. temperatureAn autoclave was cooled with an acetone/dry ice bath
  2. customthe reaction for 5 hrs
  3. customammonia was removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-6d2a53fdac464747b00effbb6bc15c8b
出典データセット
uspto-grants-2011_10
特許番号
US08030501B2

関連ノート

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