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Ammonia → HCID 136097738、化合物

HRID 1662269
ノート
印刷プレビュー

反応式

HRID 1662269 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([NH2:35])=[N:5][C:6]2([C:21]1[CH:26]=[CH:25][C:24]([O:27]C)=[C:23]([C:29]2[CH:34]=[N:33][CH:32]=[CH:31][N:30]=2)[CH:22]=1)[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1.B(Br)(Br)Br.O.N>C(Cl)Cl>[NH2:35][C:4]1[C:3]2[C:7](=[CH:8][CH:9]=[CH:10][C:2]=2[F:1])[C:6]([C:21]2[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([C:29]3[CH:34]=[N:33][CH:32]=[CH:31][N:30]=3)[CH:22]=2)([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]([F:20])([F:18])[F:19])[CH:12]=2)[N:5]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 222AmmoniaHCID 962WaterHCID 25134Boron tribromideHCID 58579508HCID 58579508、化合物

生成物 1

HCID 136097738HCID 136097738、化合物収率 33.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 4-fluoro-1-(4-methoxy-3-(pyrazin-2-yl)phenyl)-1-(2-(trifluoromethyl) pyridin-4-yl)-1H-isoindol-3-amine (0.65 g, 1.36 mmol) in DCM (12.5 ml), boron tribromide (0.718 ml, 4.20 mmol) was added dropwise at 0° C. The mixture was stirred at 0° C. for 1 hour and then allowed to reach room temperature. Water (5 ml) was added and the pH was adjusted to approx 8 with aqeuous conc. NH3. The organic phase was separated and aqueous phase was extracted with DCM (20 mL). The combined organic phases were passed through a phase separator (Sorbent) and concentrated under reduced pressure. The residue was purified twice by preparative chromatography to give the title compound (210 mg, 32%).

後処理

  1. customto reach room temperature
  2. customThe organic phase was separated
  3. extractionaqueous phase was extracted with DCM (20 mL)
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified twice by preparative chromatography

出典と根拠

ORDレコード
ord-406b9c996d5d43918ef6c96a8db9df32
出典データセット
uspto-grants-2011_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08030500B2

反応ノート

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このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート