HCID 57706034、化合物 → HCID 57706716、化合物
反応式
[F:1][C:2]([F:18])([F:17])/[C:3](/[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[CH:4]\[C:5]([O:7][CH3:8])=[O:6]>CCOC(C)=O.CO>[F:1][C:2]([F:17])([F:18])[CH:3]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)[CH2:4][C:5]([O:7][CH3:8])=[O:6]参加物
3
実験手順
A 250 mL flask containing a solution of 6.1 (2.20 g, 8.5 mmol) in 1:1 EtOAc/MeOH (40 mL) was purged with N2. To the mixture was added palladium, 10 wt. % (dry), on carbon powder, wet (0.90 g, 0.85 mmol). The vial was then purged with H2, and the contents were stirred overnight under a H2 balloon. The black mixture was filtered through a pad of Celite and concentrated to afford 6.2 (2.19 g, 99% yield).
後処理
- customwas purged with N2
- additionTo the mixture was added
- dry with materialpalladium, 10 wt. % (dry)
- customThe vial was then purged with H2
- filtrationThe black mixture was filtered through a pad of Celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-579d41fec54e4bb39873ca8eeb1aaddf
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08030354B2
反応ノート
読み込み中…