Methyl 3-(3-hydroxyphenyl)propionate → Methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

HRID 1662342ノート

反応式

HRID 1662342 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:5]=[CH:6][CH:7]=1.Cl[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=2[F:30])=[C:18]([C:31]([CH3:34])([CH3:33])[CH3:32])[CH:17]=1>>[CH3:34][C:31]([C:18]1[CH:17]=[C:16]([CH2:15][O:1][C:2]2[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:5]=[CH:6][CH:7]=2)[CH:21]=[CH:20][C:19]=1[C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[F:30])([CH3:32])[CH3:33]

参加物

3

反応物 2

HCID 1512675Methyl 3-(3-hydroxyphenyl)propionateHCID 577056714-(Chloromethyl)-2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

生成物 1

HCID 57706370Methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate収率 83%

実験手順

Methyl 3-(3-hydroxyphenyl)propanoate (commercially available from Aagile Labs Division of Tyger Scientific) (0.025 g, 0.14 mmol) was alkylated by reaction with compound 8.10 (0.043 g, 0.14 mmol) according to the method given in Example 1 to give compound 34.1 as a clear oil (0.052 g, 83% yield). MS ESI (pos.) m/e: 473.2 (M+Na)+, 468.2 (M+H2O)+.

出典と根拠

ORDレコード
ord-81fe2f87f75e4b97ad8da0aec0ee8f0d
出典データセット
uspto-grants-2011_10
特許番号
US08030354B2

反応ノート

読み込み中…