Methanol → Methyl 3-(1-(1,1-dimethylethyl)ethenyl)-4-hydroxybenzoate
反応式
[CH3:1][C:2]([C:5]([C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=1[O:17]C1CCCCO1)[C:10]([O:12][CH3:13])=[O:11])=[CH2:6])([CH3:4])[CH3:3].CO.CC1C=CC(S([O-])(=O)=O)=CC=1.C1C=C[NH+]=CC=1>>[CH3:4][C:2]([C:5]([C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=1[OH:17])[C:10]([O:12][CH3:13])=[O:11])=[CH2:6])([CH3:1])[CH3:3]参加物
4
反応条件
- 温度
- 60 °C
実験手順
To a stirred solution of 66.18C (2.500 g, 7.85 mmol) in MeOH (10.00 mL, 7.85 mmol) at 23° C. was added PPTS (0.197 g, 0.785 mmol). The reaction was heated to 60° C. and stirred for 19 hours. The reaction was then concentrated in vacuo to give a clear oil. The product was then purified on silica gel (0-20% EtOAc in hexanes) to yield 66.18D as a colorless oil (1.50 g, 81.5% yield).