Methyl (trimethylsilyl)acetate → Methyl 3-(3-(tert-butyldimethylsilyloxy)-2,5-difluorophenyl)pent-2-enoate

HRID 1662564ノート

反応式

HRID 1662564 の反応式
[Si:1]([O:8][C:9]1[C:10]([F:20])=[C:11]([C:16](=O)[CH2:17][CH3:18])[CH:12]=[C:13]([F:15])[CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C[Si]([CH2:25][C:26]([O:28][CH3:29])=[O:27])(C)C>>[Si:1]([O:8][C:9]1[C:10]([F:20])=[C:11]([C:16]([CH2:17][CH3:18])=[CH:25][C:26]([O:28][CH3:29])=[O:27])[CH:12]=[C:13]([F:15])[CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 76210Methyl (trimethylsilyl)acetateHCID 577063781-(3-(tert-Butyldimethylsilyloxy)-2,5-difluorophenyl)propan-1-one

生成物 1

HCID 67432312Methyl 3-(3-(tert-butyldimethylsilyloxy)-2,5-difluorophenyl)pent-2-enoate

実験手順

Compound 90.E (mixture of geometric isomers) was prepared from 90.D and methyl (trimethylsilyl)acetate (available from Aldrich) according to the analogous method described in Example 84.

出典と根拠

ORDレコード
ord-06ccf384821b488f91ba28cb88a127c9
出典データセット
uspto-grants-2011_10
特許番号
US08030354B2

反応ノート

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