3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → HCID 67431072、化合物

反応式

Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[OH:21][CH2:22][CH2:23][NH:24][C@@H:25]([CH3:31])[C:26]([N:28]([CH3:30])[CH3:29])=[O:27]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([N:24]([CH2:23][CH2:22][OH:21])[C@@H:25]([CH3:31])[C:26]([N:28]([CH3:30])[CH3:29])=[O:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

参加物

反応物 2

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one

HCID 86625703HCID 86625703、化合物

生成物 1

HCID 67431072HCID 67431072、化合物

実験手順

With 1.17 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 79-3 (4.18 mmol, crude form) as starting materials, respectively 0.92 g (Isomer A, colorless solid) and 0.66 g (Isomer B, colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Step 4-2.

出典と根拠

ORDレコード: ord-cccb2e80766942daaf4273c349b1fc76
出典データセット: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08030499B2

反応ノート

読み込み中…