Hydrochloric Acid → (2S,4R)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide hydrochloride

HRID 1662684ノート

反応式

HRID 1662684 の反応式
[CH3:1][N:2]([CH3:18])[C:3]([C@@H:5]1[CH2:9][C@@H:8]([OH:10])[CH2:7][N:6]1C(OC(C)(C)C)=O)=[O:4].[ClH:19]>CCOC(C)=O>[ClH:19].[OH:10][C@H:8]1[CH2:7][NH:6][C@H:5]([C:3]([N:2]([CH3:18])[CH3:1])=[O:4])[CH2:9]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 25180889(2S,4R)-tert-butyl 2-(dimethylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate

生成物 1

HCID 23535508(2S,4R)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a solution of 11.0 g of the compound obtained in Step 88-1 in EtOAc (100 ml) was added dropwise a solution of 4 mol/l hydrochloric acid in EtOAc (100 ml) over 20 minutes. The solution was stirred at room temperature for two hours and then the solvent was evaporated under reduced pressure. EtOAc was added, and the solution was stirred for 30 minutes. Thereafter, the precipitated solid was filtered and then dried to obtain 8.21 g of the title compound (colorless solid).

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionEtOAc was added
  3. stirringthe solution was stirred for 30 minutes
  4. filtrationThereafter, the precipitated solid was filtered
  5. customdried

出典と根拠

ORDレコード
ord-2acaf965bcff49daa4c1497e3f458349
出典データセット
uspto-grants-2011_10
特許番号
US08030499B2

反応ノート

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