4-Bromoanisole → 3-hydroxy-3-(4-methoxyphenyl)-5-methyl-1,3-dihydro-2H-indol-2-one

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[CH3:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]2=[O:21]>>[OH:21][C:14]1([C:2]2[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=2)[C:13]2[C:17](=[CH:18][CH:19]=[C:11]([CH3:10])[CH:12]=2)[NH:16][C:15]1=[O:20]

参加物

反応物 2

HCID 77304-Bromoanisole

HCID 118405-Methylisatin

生成物 1

HCID 52977493-hydroxy-3-(4-methoxyphenyl)-5-methyl-1,3-dihydro-2H-indol-2-one収率 81.2%

実験手順

With 5.61 g of 4-bromoanisole and 3.23 g of 5-methyl isatin as starting materials, 4.38 g of the title compound (light brown solid) was obtained by a similar method to Step 21-1.

出典と根拠

ORDレコード: ord-c774a1eb56464d2d93bdb0bab694c0df
出典データセット: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08030499B2

反応ノート

読み込み中…