2-Bromo-4-methylanisole → 4,5-dichloro-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1,3-dihydro-2H-indol-2-one

反応式

Br[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[Cl:11][C:12]1[C:20]([Cl:21])=[CH:19][CH:18]=[C:17]2[C:13]=1[C:14](=[O:23])[C:15](=[O:22])[NH:16]2>>[Cl:11][C:12]1[C:20]([Cl:21])=[CH:19][CH:18]=[C:17]2[C:13]=1[C:14]([OH:23])([C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10])[C:15](=[O:22])[NH:16]2

参加物

反応物 2

HCID 891432-Bromo-4-methylanisole

HCID 51399804,5-Dichloro-1H-indole-2,3-dione

生成物 1

HCID 231207064,5-dichloro-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1,3-dihydro-2H-indol-2-one収率 52.4%

実験手順

With 3.02 g of 2-bromo-1-methoxy-4-methyl benzene and 1.50 g of 4,5-dichloroisatin as starting materials, 1.23 g of the title compound (yellow solid) was obtained by a similar method to Step 21-1.

出典と根拠

ORDレコード: ord-0dc6a4f4d3a04484ac6f759c8da195ae
出典データセット: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08030499B2

反応ノート

読み込み中…