Boc-hyp-obzl → Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

HRID 1662723ノート

反応式

HRID 1662723 の反応式
[OH:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:3]1.[ClH:24].CCOC(C)=O>CCOC(C)=O>[ClH:24].[OH:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:3]1

参加物

4

反応物 2

HCID 11902907Boc-hyp-obzlHCID 21866389Hydrogen chloride-ethyl acetate

生成物 1

HCID 16212860Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 10.0 g of the compound obtained in Step 157-1 in EtOAc (49 ml) was added a solution of 4 mol/L hydrochloric acid/EtOAc (39 ml). The solution was stirred at room temperature for one hour. The precipitated crystal was filtered, and the crystal was washed with EtOAc. The title compound in the amount of 6.70 g (colorless solid) was obtained.

後処理

  1. filtrationThe precipitated crystal was filtered
  2. washthe crystal was washed with EtOAc

出典と根拠

ORDレコード
ord-2e21f97ab35b4a2a86719cd1c48cdde5
出典データセット
uspto-grants-2011_10
特許番号
US08030499B2

反応ノート

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