化工社化工社 化学情報印刷レポート · 研究参考用
5-chloro-1H-indole-2,3-dione → 5-chloro-3-hydroxy-3-(2-methoxy-5-morpholin-4-ylphenyl)-1,3-dihydro-2H-indol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-chloro-1H-indole-2,3-dione | HCID 87203 | — |
| 反応物 | 4-(3-Bromo-4-methoxyphenyl)morpholine | HCID 67429791 | — |
| 生成物 | 5-chloro-3-hydroxy-3-(2-methoxy-5-morpholin-4-ylphenyl)-1,3-dihydro-2H-indol-2-one | HCID 67428909 | 77.3% |
反応手順
With 2.00 g of the compound obtained in Step 191-1 and 953 mg of 5-chloroisatin as starting materials, 1.52 g of the title compound (pale yellow amorphous) was obtained by a similar method to Step 21-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030499B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-4295049017c74788805de3e2f81f0b14 |
| 出典メモ | uspto-grants-2011_10 |