Diethylamine → (4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami de

HRID 1662761ノート

反応式

HRID 1662761 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:26])([F:25])[F:24])(=[O:13])=[O:12])[C:6](=[O:27])[C:5]2([N:39]1[CH2:48][C@H:47]([OH:49])[CH2:46][C@H:40]1[C:41]([N:43]([CH3:45])[CH3:44])=[O:42])[C:28]1[CH:33]=[C:32]([CH2:34][CH:35]=O)[CH:31]=[CH:30][C:29]=1[O:37][CH3:38].[CH2:50]([NH:52][CH2:53][CH3:54])[CH3:51]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:24])([F:26])[F:25])(=[O:12])=[O:13])[C:6](=[O:27])[C:5]2([N:39]1[CH2:48][C@H:47]([OH:49])[CH2:46][C@H:40]1[C:41]([N:43]([CH3:44])[CH3:45])=[O:42])[C:28]1[CH:33]=[C:32]([CH2:34][CH2:35][N:52]([CH2:53][CH3:54])[CH2:50][CH3:51])[CH:31]=[CH:30][C:29]=1[O:37][CH3:38]

参加物

3

反応物 2

HCID 8021DiethylamineHCID 59867806HCID 59867806、化合物

生成物 1

HCID 59867874(4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami de

実験手順

With 500 mg of the compound obtained in Example 219 and diethyl amine (0.16 ml) as starting materials, 180 mg of the title compound (light yellow amorphous) was obtained by a similar method to Example 220.

出典と根拠

ORDレコード
ord-bcb58c5d8cc641bf99e21f2ef8c9fa0d
出典データセット
uspto-grants-2011_10
特許番号
US08030499B2

反応ノート

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