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5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(Cyclohexanecarboxamido)Benzoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Amino-2-chlorobenzoic acid | HCID 37879 | — |
| 反応物 | Cyclohexanecarbonyl chloride | HCID 75938 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Chloro-5-(Cyclohexanecarboxamido)Benzoic Acid | HCID 54920372 | 98.1% |
反応手順
A solution of 5-amino-2-chlorobenzoic acid (0.34 g, 2.0 mmol) in THF (10 mL) was charged with cyclohexanecarbonyl chloride (0.27 mL, 1.7 mmol). The reaction was stirred for 16 h and then concentrated in vacuo. The residue was suspended in DCM and filtered to afford the title compounds as a white solid (0.47 g, 97%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030487B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-c95b7900514f4738a107f2e40adbe181 |
| 出典メモ | uspto-grants-2011_10 |