HCID 58748735、化合物 → HCID 58748706、化合物

HRID 1662842ノート

反応式

HRID 1662842 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([NH:20][CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:19])=[O:18])=[CH:13][CH:12]=2)=[N:8][CH:9]=1)([O-])=O>CO>[NH2:1][C:4]1[CH:9]=[N:8][C:7]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([NH:20][CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:19])=[O:18])=[CH:13][CH:12]=2)=[N:6][CH:5]=1

参加物

3

反応物 1

HCID 58748735HCID 58748735、化合物

生成物 1

HCID 58748706HCID 58748706、化合物収率 7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Intermediate 44 (Example 92) (4.26 mmol, 1.0 equiv) dissolved in MeOH (0.05-1.0 M) was evacuated of air and placed under an argon blanket; Pd/C (10% by wt) was then added. The mixture was evacuated and then refilled with hydrogen and stirred at room temperature for 4 h. Filtration through CELITE with a MeOH wash, followed by concentration under reduced pressure afford the title compound as a white solid (100 mg, 7%). The crude amino-compound was used in the next step without purification. MS (ES+): m/z=363 (M+H)+. LC retention time: 1.34 min.

後処理

  1. customwas evacuated of air
  2. additionPd/C (10% by wt) was then added
  3. customThe mixture was evacuated
  4. additionrefilled with hydrogen
  5. filtrationFiltration through CELITE with a MeOH
  6. washwash
  7. concentrationfollowed by concentration under reduced pressure

出典と根拠

ORDレコード
ord-7dcf97b9a48b40068d70ebfb68a5f9ae
出典データセット
uspto-grants-2011_10
特許番号
US08030487B2

反応ノート

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