1-(2-Hydroxyethyl)piperazine → (5-Bromo-pyridin-2-yl)-(4-(2-hydroxy-ethyl)-piperazin-1-yl)-methanone

HRID 1662843

反応式

HRID 1662843 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[N:11]1([CH2:17][CH2:18][OH:19])[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:14]2[CH2:15][CH2:16][N:11]([CH2:17][CH2:18][OH:19])[CH2:12][CH2:13]2)=[O:10])=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 6085445-Bromopyridine-2-carboxylic acid

生成物 1

HCID 58748747(5-Bromo-pyridin-2-yl)-(4-(2-hydroxy-ethyl)-piperazin-1-yl)-methanone

実験手順

The title compound was prepared from 5-bromo-pyridine-2-carboxylic acid (1.0 g, 5.0 mmol) and 2-piperazin-1-yl-ethanol (1.0 g, 7.7 mmol) according to Method A (Example 89). After the removal of solvent, the residue was triturated in hexane-Et2O (5:1 v/v) and the white solid filtered (1.0 g, 65%).

後処理

  1. customAfter the removal of solvent
  2. customthe residue was triturated in hexane-Et2O (5:1 v/v)
  3. filtrationthe white solid filtered (1.0 g, 65%)

出典と根拠

ORDレコード
ord-569c74c6f5a64960b2cc5d88a1556b5b
出典データセット
uspto-grants-2011_10
特許番号
US08030487B2

関連ノート

読み込み中…