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Triphenylphosphine → 3-Bromo-4-(3-methoxy-benzyloxy)-5-nitro-benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 3-Methoxybenzyl alcohol | HCID 81437 | — |
| 反応物 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 反応物 | 3-Bromo-4-hydroxy-5-nitrobenzaldehyde | HCID 1494378 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Bromo-4-(3-methoxy-benzyloxy)-5-nitro-benzaldehyde | HCID 86625158 | — |
反応手順
To a solution of 3-bromo-4-hydroxy-5-nitro-benzaldehyde (87.4 mg) in dry dichloromethane (7.5 ml) was added 3-methoxybenzyl alcohol (35 μl), triphenylphosphine (103 mg) and diethyl azodicarboxylate (45 μl). The mixture was stirred under a nitrogen atmosphere for 17 h and then concentrated in vacuo. The residue was purified by chromatography on silicagel in heptane/ethyl acetate 9/1→1/1 (v/v) as eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08034945B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-8058568de9b44bb98faec1b0d7f1cddd |
| 出典メモ | uspto-grants-2011_10 |