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HRID 1663363作成日：2026年10月25日
5-Propylcyclohexane-1,3-dione → 4-[3-Bromo-4-(3-methoxy-benzyloxy)-5-nitro-phenyl]-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile
https://huagongshe.com/reaction/1663363
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Propylcyclohexane-1,3-dione | HCID 2737224 | — |
| 反応物 | 3-Aminocrotonitrile | HCID 5324720 | — |
| 反応物 | 3-Bromo-4-(3-methoxy-benzyloxy)-5-nitro-benzaldehyde | HCID 86625158 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-[3-Bromo-4-(3-methoxy-benzyloxy)-5-nitro-phenyl]-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile | HCID 11949649 | — |
反応手順
A mixture of 3-bromo-4-(3-methoxy-benzyloxy)-5-nitro-benzaldehyde (50 mg), 3-aminocrotonitrile (13 mg) and 5-propylcyclohexane-1,3-dione (25 mg) in 10 ml of ethanol was stirred at 80° C. for 17 h. The mixture was concentrated in vacuo. The residue was purified by chromatography on silicagel in heptane/ethyl acetate 8/2→1/1 (v/v) as eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08034945B2 |
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| 出典データセット | uspto-grants-2011_10 |
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| ORD ID | ord-9c6cb09aada94387b3abdea5423bd469 |
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| 出典メモ | uspto-grants-2011_10 |
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