3-Bromo-4-hydroxy-5-nitrobenzaldehyde → HCID 67435380、化合物

HRID 1663385ノート

反応式

HRID 1663385 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10])[CH:5]=O.[CH3:14]/[C:15](/[NH2:19])=[CH:16]\[C:17]#[N:18].[CH2:20]([CH:23]1[CH2:28][C:27](=[O:29])[CH2:26][C:25](=O)[CH2:24]1)[CH2:21][CH3:22]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]2[C:26]3[C:27](=[O:29])[CH2:28][CH:23]([CH2:20][CH2:21][CH3:22])[CH2:24][C:25]=3[NH:19][C:15]([CH3:14])=[C:16]2[C:17]#[N:18])[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10]

参加物

5

反応物 3

HCID 14943783-Bromo-4-hydroxy-5-nitrobenzaldehydeHCID 27372245-Propylcyclohexane-1,3-dioneHCID 53247203-Aminocrotonitrile

生成物 1

HCID 67435380HCID 67435380、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of 3-bromo-4-hydroxy-5-nitro-benzaldehyde (18.26 g), 3-aminocrotonitrile (6.09 g) and 5-propylcyclohexane-1,3-dione (11.45 g) in ethanol (250 ml) was stirred at 80° C. for 17 h. The mixture was concentrated in vacuo. The residue was purified by chromatography on silicagel in dichloromethane as eluent.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residue was purified by chromatography on silicagel in dichloromethane as eluent

出典と根拠

ORDレコード
ord-5ded5b8bd1f84c27b4dbc561ba532673
出典データセット
uspto-grants-2011_10
特許番号
US08034945B2

反応ノート

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