関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Phosphate, Dibasic | HCID 24203 | — |
| 反応物 | 6-Iodopyridazin-3-amine | HCID 10867834 | — |
| 反応物 | tert-Butyl (2-chloroacetyl)carbamate | HCID 14221822 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | Tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate | HCID 46941915 | 63% |
反応手順
To a solution of 3-amino-6-iodopyridazine (10.0 g, 45.2 mmol) in N,N-dimethylacetamide (100 mL) were added tert-butyl (chloroacetyl)carbamate (14.0 g, 72.4 mmol) and disodium hydrogenphosphate (16.1 g, 113 mmol), and the mixture was stirred at 120° C. for 3 hr. After cooling the mixture to room temperature, water (400 mL) was added to the mixture, and the precipitated crystals were filtrated, and washed with acetonitrile and petroleum ether to give the title compound (10.2 g, 63%) as a green powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08034812B2 |
|---|
| 出典データセット | uspto-grants-2011_10 |
|---|
| ORD ID | ord-a0e9ff83a97a417aa675e8332b54e6f3 |
|---|
| 出典メモ | uspto-grants-2011_10 |
|---|
