Ethyl 6-Iodoimidazo[1,2-b]pyridazine-2-carboxylate → 6-iodo-N-methylimidazo[1,2-b]pyridazine-2-carboxamide
反応式
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([O:13]CC)=O)[N:10]=2)[N:7]=1.[CH3:16][NH2:17].O1CCCC1>CO>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:17][CH3:16])=[O:13])[N:10]=2)[N:7]=1参加物
4
実験手順
To a suspension of ethyl 6-iodoimidazo[1,2-b]pyridazine-2-carboxylate (4.5 g, 14.8 mmol) in methanol (13.5 mL) was added dropwise a solution of methylamine/tetrahydrofuran (2 mol/L, 37.1 mL, 74.2 mmol), and the mixture was stirred at room temperature for 96 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate, saturated brine and water to give the title compound (3.2 g, 71%) as a dark brown powder.
後処理
- customThe solvent was evaporated under reduced pressure
- washthe residue was washed with ethyl acetate, saturated brine and water
出典と根拠
- ORDレコード
- ord-60a707966e3f4d2a9b068881a61dc94f
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08034812B2
反応ノート
読み込み中…