2,5-Dimethyl-2H-pyrazole-3-carbonyl chloride → N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 1663756

反応式

HRID 1663756 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[O:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([NH:15][C:16](=[O:20])[CH2:17][O:18][CH3:19])[N:14]=2)[N:11]=1.[CH3:24][N:25]1[C:29]([C:30](Cl)=[O:31])=[CH:28][C:27]([CH3:33])=[N:26]1>CN(C)C(=O)C>[CH3:19][O:18][CH2:17][C:16]([NH:15][C:13]1[N:14]=[C:9]2[CH:8]=[CH:7][C:6]([O:5][C:4]3[CH:3]=[C:2]([NH:1][C:30]([C:29]4[N:25]([CH3:24])[N:26]=[C:27]([CH3:33])[CH:28]=4)=[O:31])[CH:23]=[CH:22][CH:21]=3)=[N:11][N:10]2[CH:12]=1)=[O:20]

参加物

4

反応物 2

HCID 27362992,5-Dimethyl-2H-pyrazole-3-carbonyl chlorideHCID 57505512N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]-2-methoxyacetamide

生成物 1

HCID 57505513N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide収率 64%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

Using N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]-2-methoxyacetamide (200 mg, 0.64 mmol), 1,3-dimethyl-1H-pyrazole-5-carbonyl chloride (162 mg, 1.02 mmol) and N,N-dimethylacetamide (4.0 mL) as starting materials and in the same manner as in Example 120, the title compound (176 mg, 64%) was obtained as a white powder.

出典と根拠

ORDレコード
ord-02f5847f3e514ca6814c80ef181b3702
出典データセット
uspto-grants-2011_10
特許番号
US08034812B2

関連ノート

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