反応式
Cl.[NH2:2][C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][C:8]([O:11][C:12]3[CH:13]=[CH:14][C:15]([CH3:28])=[C:16]([NH:18][C:19]([C:21]4[N:25]([CH3:26])[N:24]=[C:23]([CH3:27])[CH:22]=4)=[O:20])[CH:17]=3)=[N:7][N:6]2[CH:29]=1.[CH3:30][C:31]([CH3:36])=[CH:32][C:33](Cl)=[O:34]>CN(C)C(=O)C>[CH3:26][N:25]1[C:21]([C:19]([NH:18][C:16]2[CH:17]=[C:12]([O:11][C:8]3[CH:9]=[CH:10][C:5]4[N:6]([CH:29]=[C:3]([NH:2][C:33](=[O:34])[CH:32]=[C:31]([CH3:36])[CH3:30])[N:4]=4)[N:7]=3)[CH:13]=[CH:14][C:15]=2[CH3:28])=[O:20])=[CH:22][C:23]([CH3:27])=[N:24]1参加物
4
実験手順
In the same manner as in Example 264 and using N-{5-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]-2-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide hydrochloride (200 mg, 0.48 mmol), 3-methylbut-2-enoylchloride (81 μL, 0.73 mmol) and N,N-dimethylacetamide (5 mL) as starting materials, the title compound (150 mg, 68%) was obtained as a pale-yellow solid.
出典と根拠
- ORDレコード
- ord-b2305265517a487ca55788f506e02633
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08034812B2
関連ノート
読み込み中…