化工社化工社 化学情報印刷レポート · 研究参考用
Adipic Dihydrazide → Amikacin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Adipic Dihydrazide | HCID 66117 | — |
| 反応物 | Amikacin Sulfate Salt | HCID 5458175 | — |
| 反応物 | (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol sulfate | HCID 86619106 | — |
| 反応物 | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide sulfate | HCID 86619108 | — |
| 反応物 | tobramycin sulfate clindamycin HCl | HCID 131729235 | — |
| 生成物 | Amikacin | HCID 37768 | — |
反応手順
Amikacin Sulfate (100 mg), DBM (200 mg), and 8 mg of adipic acid dihydrazide were placed into a beaker and mixed thoroughly. Oxidized dextran solution (Mw, 500,000; 66 mg/ml; 1 ml) was added to the mixture. Tobramycin-sulfate or tobramycin-sulfate/clindamycin-HCl (1/1) can be used in place of amikacin-sulfate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08039021B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-f1c377f4273646c9a4a40597dec3cc2f |
| 出典メモ | uspto-grants-2011_10 |