関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Bromo-2-methylpropane | HCID 6555 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one | HCID 69714 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(2-Isobutoxy-5-methoxyphenyl)ethanone | HCID 68436205 | — |
反応手順
A mixture of 10 g (0.06 mol) of 2′-hydroxy-5′-methoxyacetophenone, 2.6 g (0.066 mol) of 60% sodium hydride and 150 ml of dimethylformamide is heated for one hour at 80° C. 7.2 ml (0.066 mol) of 1-bromo-2-methylpropane are added dropwise. The mixture is heated for ten hours at 80° C. and is then poured into ice-water and extracted with ether. The ether solution is washed with normal sodium hydroxide solution. The dried (Na2SO4) organic phase is evaporated under reduced pressure (8.2 g; 62%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07737176B2 |
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| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-019353d7e69c489b850181b2c519559a |
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| 出典メモ | uspto-grants-2010_06 |
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