Triethylamine → HCID 178446149、化合物

HRID 1664560ノート

反応式

HRID 1664560 の反応式
[CH2:1]([C:8]1[N:12]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=O)[O:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([N:23]1[C:31]2[N:30]=[C:29]([C:32]([F:35])([F:34])[F:33])[NH:28][C:27]=2[C:26](=[O:36])[NH:25]/[C:24]/1=[N:37]\[NH2:38])[CH2:19][CH2:20][CH2:21][CH3:22].F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.C(N(CC)CC)C>CN(C=O)C.CCOC(C)=O>[CH2:1]([C:8]1[N:12]=[C:11]([CH2:13][CH2:14][C:15]([NH:38]/[N:37]=[C:24]2\[NH:25][C:26](=[O:36])[C:27]3[NH:28][C:29]([C:32]([F:35])([F:34])[F:33])=[N:30][C:31]=3[N:23]\2[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:17])[O:10][N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 4

HCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 398703933-(3-Benzyl-1,2,4-oxadiazol-5-yl)propanoic acidHCID 178446162HCID 178446162、化合物

生成物 1

HCID 178446149HCID 178446149、化合物収率 98.6%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

The mixture of 3-(3-benzyl-1,2,4-oxadiazol-5-yl)propanoic acid (100.0 mg, 0.431 mmole), (2E)-3-pentyl-8-(trifluoromethyl)-3,7-dihydro-1H-purine-2,6-dione 2-hydrazone (144.1 mg, 0.474 mmole), BOP (209.5 mg, 0.474 mmole) and triethylamine (0.120 ml, 0.861 mmole). in DMF (4 ml) was stirred at room temperature overnight. The mixture was diluted with EtOAc (100 ml) and washed with water, then brine. The organic phase was dried over Na2SO4, filtrated and concentrated to give the desired product (220.1 mg, 98.6%) as yellowish oil. LCMS calculated for C23H26F3N8O3 (M+H): m/z=5192. found 519.2.

後処理

  1. washwashed with water
  2. dry with materialThe organic phase was dried over Na2SO4
  3. filtrationfiltrated
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-27297a3075f34dba8a065a9465737bde
出典データセット
uspto-grants-2011_10
特許番号
US08039478B2

反応ノート

読み込み中…