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Methyl iodide → 6-Bromo-1-methyl-1H-indazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 6-Bromo-1H-indazole | HCID 17842471 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 6-Bromo-1-methyl-1H-indazole | HCID 22558675 | — |
反応手順
6-Bromoindazole (400 mg) was dissolved in methanol (10 mL). To this solution, potassium hydroxide (450 mg) was added followed by methyl iodide (0.50 mL) and the mixture was refluxed for 2.5 h. The reaction was cooled, diluted with diethyl ether, washed with water, brine, dried and concentrated. The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08039471B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-f391e8ec558c4f93a563fe826edb395a |
| 出典メモ | uspto-grants-2011_10 |