Hydrochloric Acid → 1-Ethoxy-4,4,4-trifluoro-1-oxobutan-2-aminium chloride

反応式

[NH2:1][CH:2]([CH2:6][C:7]([F:10])([F:9])[F:8])[C:3]([OH:5])=[O:4].[ClH:11].[CH2:12](O)[CH3:13]>>[Cl-:11].[CH2:12]([O:4][C:3](=[O:5])[CH:2]([NH3+:1])[CH2:6][C:7]([F:10])([F:9])[F:8])[CH3:13]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 3530832-Amino-4,4,4-trifluorobutanoic acid

生成物 1

HCID 866201251-Ethoxy-4,4,4-trifluoro-1-oxobutan-2-aminium chloride

反応条件

温度: 85 °C

実験手順

2-Amino-4,4,4-trifluorobutanoic acid (11.7 g, 52.8 mmol) was added to a saturated solution of HCl in ethanol (100 mL) and heated to 85° C. After 4 h, the mixture was allowed to cool to ambient temperature and concentrated. MS 186.0 (M+1).