Acetyl chloride → HCID 178471808、化合物

HRID 1664987ノート

反応式

HRID 1664987 の反応式
Cl.[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9][CH2:8]1)[CH3:3].CCN(CC)CC.[C:22](Cl)([CH3:24])=[O:23]>C(Cl)Cl>[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([NH:13][C:22](=[O:23])[CH3:24])[CH2:11][CH2:12]1)[CH3:3]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 178471807HCID 178471807、化合物2 回

生成物 1

HCID 178471808HCID 178471808、化合物収率 82.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(trans-4-Amino-cyclohexyl)-acetic acid ethyl ester hydrochloride (10.0 g, 45 mmol, intermediate B) was dissolved in CH2Cl2 (150 ml) and Et3N and AcCl (3.89 g, 50 mmol) were added. The reaction mixture was stirred 3 h at room temperature before washing it with H2O and brine. After drying (Na2SO4) the solvent was evaporated to yield 8.42 g (82%, 37 mmol) of a white solid. MS (m/z): 228.3 ([M+H]+).

後処理

  1. washbefore washing it with H2O and brine
  2. dry with materialAfter drying (Na2SO4) the solvent
  3. customwas evaporated

出典と根拠

ORDレコード
ord-dcc0237461bb47f4b3b2fe28754988b0
出典データセット
uspto-grants-2011_10
特許番号
US08039490B2

反応ノート

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