Isobutyl iodide → 2-chloro-N-isobutyl-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide

HRID 1665023

反応式

HRID 1665023 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][CH2:12][C:13]1[S:17][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:19]=2)=[N:15][CH:14]=1)(=[O:10])=[O:9].I[CH2:29][CH:30]([CH3:32])[CH3:31].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]([CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:12][C:13]1[S:17][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([S:24]([CH3:27])(=[O:25])=[O:26])[CH:19]=2)=[N:15][CH:14]=1)(=[O:10])=[O:9]

参加物

5

反応物 3

HCID 10556Isobutyl iodideHCID 10796Cesium carbonateHCID 674399132-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide

生成物 1

HCID 252343872-chloro-N-isobutyl-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

In analogy to example 10, step 3, 2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide (example 10, step 2) was reacted with 1-iodo-2-methylpropane and cesium carbonate in N,N-dimethylacetamide to give 2-chloro-N-isobutyl-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide as a colorless solid. MS: 499.0 ([M+H]+)

出典と根拠

ORDレコード
ord-96a985abf37b495894b6939eaa86b7ea
出典データセット
uspto-grants-2011_10
特許番号
US08039493B2

関連ノート

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