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Benzoyl chloride → N-benzoyl-2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide | HCID 67439913 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-benzoyl-2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide | HCID 25234388 | — |
反応手順
In analogy to example 6, 2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide (example 10, step 2) was reacted with benzoyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-benzoyl-2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide as a colorless solid. MS: 548.7 ([M+H]+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08039493B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-7b8b6e96da754115a68d0246a4745216 |
| 出典メモ | uspto-grants-2011_10 |