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Sodium Carbonate → 2-chloro-N-isobutyl-N-[4-(5-methanesulfonyl-pyridin-3-yl)-thiophen-2-ylmethyl]-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 5-(Methylsulphonyl)pyridine-3-boronic acid | HCID 44119381 | — |
| 反応物 | N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67439155 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 生成物 | 2-chloro-N-isobutyl-N-[4-(5-methanesulfonyl-pyridin-3-yl)-thiophen-2-ylmethyl]-benzenesulfonamide | HCID 25234322 | — |
反応手順
In analogy to example 1, step 3, N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide (example 14, step 2) was reacted with 5-(methylsulfonyl)-3-pyridineboronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give 2-chloro-N-isobutyl-N-[4-(5-methanesulfonyl-pyridin-3-yl)-thiophen-2-ylmethyl]-benzenesulfonamide as an off-white solid. MS: 557.1 ([M+OAc]−)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08039493B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-84ec80d3f4534219b5e84c573fb4ac37 |
| 出典メモ | uspto-grants-2011_10 |