HCID 67086814、化合物 → HCID 67086706、化合物
反応式
C(OC(=O)[NH:7][C@@H:8]([C:23](=[O:25])[NH2:24])[CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C(C)(C)C)=[CH:14][CH:13]=1)(C)(C)C>Cl.CCOCC>[NH2:7][C@H:8]([CH2:9][CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=1)[C:23]([NH2:24])=[O:25]参加物
4
実験手順
A solution of [(R)-4-(4-tert-Butoxy-phenyl)-1-carbamoyl-butyl]-carbamic acid tert-butyl ester (167 g, 458 mmol) in 1 M HCl in Et2O (4000 ml) is stirred at room temperature for 3 days. After this time, a white solid forms which is collected by filtration and washed with Et2O to yield (R)-2-Amino-5-(4-hydroxy-phenyl)-pentanoic acid amide; [M+H]+ 209
後処理
- filtrationAfter this time, a white solid forms which is collected by filtration
- washwashed with Et2O
出典と根拠
- ORDレコード
- ord-fb0c8e76bc89406689299d9deb71328f
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039472B2
反応ノート
読み込み中…