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Potassium Hydroxide → 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid methyl ester | HCID 67150368 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid | HCID 58271190 | 93.2% |
反応手順
3-(2′,4′,5′-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid methyl ester (2.9 g, 7.79 mmol) and 2N KOH (15.6 mL, 31.2 mmol) in 140 mL MeOH were reacted as above to yield 2.6 g (93.2%) of 3-(2′,4′,5′-trifluoro-biphenyl-4-yloxymethyl)-benzoic acid. LC-MS (ES) calculated for C20H13F3O3, 358.32; found m/z 357.1 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08039495B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-609658ca5e9d4318a596d2c7c9fcae05 |
| 出典メモ | uspto-grants-2011_10 |