2-((1-Methylethoxy)methyl)oxirane → 1'-(2-Hydroxy-3-isopropoxypropyl)spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

関与物質

反応手順

Compound 169 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 2-(isopropoxymethyl)oxirane and conditions outlined in procedure X. M.p.=97-99° C.; 400 MHz 1H NMR (DMSO-d6) δ: 7.95-7.9 (m, 1H), 7.94-7.7 (m, 2H), 7.65-7.5 (m, 1H), 4.42 (br. s, 1H), 3.72 (br. s, 1H), 3.6-3.45 (m, 1H), 3.35-3.2 (m, 2H), 3.07 (s, 2H), 2.8 (m, 2H), 2.5-2.2 (m, 4H), 2.05-1.7 (m, 4H), 1.07 (d, J=5.2 Hz, 6H); LCMS: 418 [M+H].

情報源と証拠