関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Piperidine, 1-(4-nitrophenyl)- | HCID 81049 | 533.4% |
反応手順
Piperidine (362 mg, 0.2 mmol) was added to a solution of 1-fluoro-4-nitro-benzene (200 mg, 1.4 mmol) in DMSO (10 mL) and the mixture was stirred at 80° C. for 20 hours. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with brine solution, dried over Na2SO4 and concentrated to afford 220 mg (75%) of 1-(4-nitro-phenyl)-piperidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08039463B2 |
|---|
| 出典データセット | uspto-grants-2011_10 |
|---|
| ORD ID | ord-67afc154e5e346ec8477de2d794ad9fe |
|---|
| 出典メモ | uspto-grants-2011_10 |
|---|
