Hydrochloric Acid → 1-(3-Fluorobenzoyl)piperazine hydrochloride

HRID 1665664

反応式

HRID 1665664 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[F:21][C:17]1[CH:16]=[C:15]([C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[O:22])[CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 578758094-(3-Fluoro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 545927941-(3-Fluorobenzoyl)piperazine hydrochloride収率 89%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A cold solution of 4-(3-fluoro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (400 mg, 1.29 mmol) in 1,4-dioxane.HCl (1 mL) was stirred at 0° C. for 1 hour. The reaction mixture was then concentrated under reduced pressure and the resulting crude residue was washed with ether and dried to afford 280 mg (89%) of (3-fluoro-phenyl)-piperazin-1-yl-methanone.hydrochloride.

後処理

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. washthe resulting crude residue was washed with ether
  3. customdried

出典と根拠

ORDレコード
ord-b06d171eef854b5f99d89c4b917b89e0
出典データセット
uspto-grants-2011_10
特許番号
US08039463B2

関連ノート

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