Diethyl methylmalonate → 3-Methoxy-2-methyl-3-oxopropanoic acid

HRID 1665674

反応式

HRID 1665674 の反応式
[OH-].[K+].[CH2:3]([O:5][C:6](=[O:14])[CH:7]([CH3:13])[C:8]([O:10]CC)=[O:9])C>CO>[CH3:3][O:5][C:6](=[O:14])[CH:7]([CH3:13])[C:8]([OH:10])=[O:9]

参加物

4

反応物 2

HCID 11857Diethyl methylmalonateHCID 14797Potassium Hydroxide

生成物 1

HCID 3006933-Methoxy-2-methyl-3-oxopropanoic acid収率 47.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

KOH (386 mg, 6.88 mmol) was added to a solution 2-methyl-malonic acid diethyl ester (1 g, 5.74 mmol) in methanol (7 mL). The resulting mixture was stirred overnight at ambient temperature then concentrated. The resulting residue was diluted with water, acidified with conc. HCl and the product was extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 360 mg (47%) of 2-methyl-malonic acid monomethyl ester

後処理

  1. concentrationthen concentrated
  2. additionThe resulting residue was diluted with water
  3. extractionthe product was extracted with dichloromethane
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ffa459bab6874c01a1a05d203d9280f9
出典データセット
uspto-grants-2011_10
特許番号
US08039463B2

関連ノート

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